How much does a Neapolitan Mastiff puppy cost?

Neapolitan Mastiff puppies don’t come cheap, and that $2,000 to $5,000 price tag isn’t just for the wow factor of their massive size and dramatic wrinkles. Responsible breeders aren’t flipping puppies for profit—they’re managing a high-stakes operation. These dogs are prone to serious health issues like hip and elbow dysplasia, bloat, cherry eye, and entropion, so ethical breeders invest heavily in health testing. That means OFA certifications, eye exams, and sometimes even genetic panels, all before breeding a single dog. Those costs get passed on. Then there’s the breeding itself: Neos often need C-sections due to their size and the puppy’s head shape, which adds $1,500 or more in vet fees per litter. With a popularity rank of 102, demand isn’t sky-high, but supply is tightly controlled because breeding them safely is expensive and risky. Most reputable breeders only produce a few litters a year, if that. So if you see a Neapolitan Mastiff puppy for under $1,500, walk away. That price likely means skipped health tests, poor breeding practices, or worse—a puppy mill. You’re not just buying a dog, you’re paying for responsible stewardship of a fragile, powerful breed. Cut corners here, and you’ll pay later—both emotionally and in vet bills.